Schwannoma
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Tissue components: Bimodal Antoni, Type A: Cellular, closely packed; Verocay bodies; Whorls Antoni, Type B: Loose, myxoid Vessels, Intermediate-sized: Sclerotic, Thick walls Axons: No intratumoral Cells Tapered ends Nuclei spindled Palisading: Verocay bodies Mitotic figures: Few Cell components Uniform: Differentiated Schwann cells Different from Neurofibroma which has Mixed cell types Malignant transformation: Rare Immunoreactivity S-100 protein (100%) > Leu-7 CD56 (NCAM) SOX10 Calbindin 2 (Calretinin; CALB2) : Strong Collagen IV Collagen VI INI1 Ki-67: Scattered cells Variable: CD34 No: Epithelial membrane antigen (EMA); Desmin; Neurofilament; Factor XIIIal |
 H&E stain |
Antoni A tissue: Dense
Vessels, Intermediate sized; Thick walls
 H&E stain |
Whorls
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 H&E stain |
Whorls
 H&E stain |
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H&E stain |
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H&E stain |
 Collagen IV stain |
Dark staining of connective tissue in neoplasm
 Collagen IV stain |
 Collagen IV stain |
 H&E stain |
Palisaded nuclei
 H&E stain |
 H&E stain |
Antoni B tissue (Left)
 H&E stain |
Antoni B tissue (bottom)
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 H&E stain |
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 H&E stain |
 H&E stain |
Uniform: Differentiated Schwann cells
Different from Neurofibroma which has Mixed cell types
 H&E stain |
 H&E stain |
 H&E stain |
Vessels: Thick walls
 H&E stain |
 Collagen IV stain |
 S100 stain |
 S100 stain |
 S100 stain |
 S100 stain |
 S100 stain |
 S100 stain |
 SOX10 stain |
 SOX10 stain |
 SOX10 stain |
 SOX10 stain |
 SOX10 stain |
 Ki-67 stain |
 Ki-67 stain |
 Ki-67 stain |
 Ki-67 stain |
INI1
Stains cells in Schwannoma
May have mosic loss of staining: More in familial cases
 INI1 stain |
EMA: No staining of cells in Schwannoma
 EMA stain |
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4/17/2025