HEMOSIDERIN
- Stain: Prussian blue
- Description
- Brown, insoluble, granular pigment
- Contain: Iron
- Location: Extracellular; Within macrophages
- Disorders: Hemosiderin deposits in muscle or nerve occur in
- Hemosiderosis
- Hemochromatosis
- Other systemic iron overload
- Local hemorrhage
- Tissue Locations
Hemosiderin deposits: Endomysial
![](../pics/biopsy/vesselsm/hemosidgthp.jpg)
Gomori trichrome stain
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![](../pics/biopsy/vesselsm/hemosidnadh2.jpg)
NADH stain
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Hemosiderin deposits: Around enlarged endomysial capillaries
![](../pics/biopsy/vesselsm/hemosidnadh3.jpg)
NADH stain
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![](../pics/biopsy/vesselsm/hemosidcr.jpg)
Congo red stain
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![](../pics/biopsy/vesselsm/hemosiderinhe.jpg)
H&E stain
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Hemosiderin deposits
Around endomysial capillaries (Enlarged, with thick walls)
May also be present in
perimysium in vasculitis
Hemosiderin deposits
Outside vessel walls
Within a cluster of large capillaries
![](../pics/biopsy/vesselsm/hemosidgt.jpg)
Gomori trichrome stain
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![](../pics/biopsy/vesselsm/hemosidc5b9hp2.jpg)
C5b-9 stain
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Hemosiderin Deposits: Associated with capillary pathology
C
5b-9 deposiits
Large size
![](../pics/biopsy/vesselsm/hemosidulex.jpg)
Ulex stain
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Hemosiderin deposits: Epineurial
![](../pics/biopsy/vesselsm/hemosidepineurgtlp.jpg)
Gomori trichrome stain
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![](../pics/biopsy/vesselsm/hemosidepineurgtmp.jpg)
Gomori trichrome stain
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![](../pics/biopsy/vesselsm/prusblue2.jpg)
Prussian blue stain
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Prussian blue stain: Iron in muscle with endomysial hemosiderin depositis
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6/1/2023