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HEMOSIDERIN

• Stain: Prussian blue
• Description
  • Brown, insoluble, granular pigment
  • Contain: Iron
  • Location: Extracellular; Within macrophages
• Disorders: Hemosiderin deposits in muscle or nerve occur in
  • Hemosiderosis
  • Hemochromatosis
  • Other systemic iron overload
  • Local hemorrhage
    • Trauma
    • Vasculitis & Vasculopathy
  • Tissue Locations
    • Endomysium: Near capillaries
    • Epineurium: Near vessels
    • Perimysium: Near vessels

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Hemosiderin deposits: Endomysial

Gomori trichrome stain

NADH stain

Hemosiderin deposits: Around enlarged endomysial capillaries

NADH stain

Congo red stain

H&E stain

Hemosiderin deposits
  Around endomysial capillaries (Enlarged, with thick walls)
  May also be present in perimysium in vasculitis

NADH stain

Hemosiderin deposits
  Outside vessel walls
  Within a cluster of large capillaries

Gomori trichrome stain

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C5b-9 stain

Hemosiderin Deposits: Associated with capillary pathology
  C_5b-9 deposiits
  Large size

Ulex stain

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Hemosiderin deposits: Epineurial

Gomori trichrome stain

Gomori trichrome stain

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Prussian blue stain
Prussian blue stain: Iron in muscle with endomysial hemosiderin depositis

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6/1/2023