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PATHWAYS: GLYCOGEN & GLUCOSE

Carbohydrate Glucose to Pyruvate   Animation Glycogenolysis Glycolysis Glycogen disorders Also see   Lipid metabolism

From: R Brian Sommerville

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Glycogenolysis Pathway

Glycogen: Normal Morphology: 20 nm particle Composition Glucose units Chains: α-1,4-glucosidic linkage Branches: α-1,6-glucosidic linkage Protein core: Glycogenin Polyglucosan Glycogen Phosphorylase (PYGM) Removes glucose residues from α-(1,4)-linkages within glycogen molecules Product of reaction: Glucose-1-phosphate. Phosphoglucomutase Converts glucose-1-phosphate to glucose-6-phosphate. Skeletal muscle: Glucose-6-phosphate is then metabolized by the glycolytic pathway Diseases: CDG1t; GSD14 Phosphorylase b kinase Reactivates phosphorylase by phosphorylating it Debrancher enzyme Removes glucose from branch points (α-(1,6)-linkages) within glycogen Hexokinase Phosphorylates this glucose Phosphorylated glucose then enters the glycolytic pathway

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Glycolysis Pathway

Also see: MedicalBiochemistry

Progressive changes Glycolysis of glucose to pyruvate. = Adenosine = Phosphate From University of Virginia

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5/22/2020