SPINAL MUSCULAR ATROPHY: Lower Extremity, Dominant
SMA-LED: Early pathology (2 year-old patient)
Denervation in muscle
 H & E stain |
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Morphology Small & intermediate-sized angular & polygonal muscle fibers Grouped muscle fiber atrophy Hypertrophic muscle fibers Internal nuclei |
 H & E stain |
 H & E stain |
Inflammation: Mononuclear cells surround Intermediate-sized perimysial vessels |
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 H & E stain |
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Muscle fibers: Intermediate-sized & Small; Polygonal, Angular or Very small, Rounded (Pyknotic clunps)
 Esterase stain |
Muscle fibers: Internal architecture NADH stain |
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Large muscle fibers Coarse internal architecture Pale centers |
Muscle: Fiber types
 ATPase, pH 9.4 |
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Large muscle fibers: Type 2 predominance |
 ATPase, pH 4.3 |
SMA-LED: Late stage muscle (22 years-old) H & E stain |
 GT stain |
Muscle fibers: Small, Rounded
Endomysial connective tissue: Greatly increased
Small muscle fibers: Esterase stained
 Esterase stain |
Muscle spindles: Preserved H&E stain |
 H&E stain |
Intramuscular nerve: Reduced staining on VvG VvG stain |
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12/21/2012