From:
Chunyu (Hunter) Cai
![](../pics/biopsy/lgd/plectin/lgd1qhefix.jpg)
H&E stain
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Myopathic features
Muscle Fibers
Necrosis: Scattered
Size: Varied
Nuclei: Internal; Often clustered
Cytoplasm: Irregular clear regions
Endomysial connective tissue: Increased
![](../pics/biopsy/lgd/plectin/lgd1qhe.jpg)
H&E stain
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![](../pics/biopsy/lgd/plectin/lgd1qhehp.jpg)
H&E stain
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![](../pics/biopsy/lgd/plectin/lgd1qdesmin.jpg)
Desmin stain
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Muscle fiber Aggregates
Punctate cytoplasmic staining for Desmin & Dysferlin
![](../pics/biopsy/lgd/plectin/lgd1qdysferlin.jpg)
Dysferlin stain
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Muscle fiber Aggregates
Muscle fiber Aggregates
Subsarcolemmal filamentous collections
Muscle fiber pathology
Subsarcolemmal Z-band disruption & separation from surface membrane
Nuclear Pathology
Chains
Nuclear Pathology
Clusters
Mitochondrial Pathology
![](../pics/biopsy/lgd/plectin/lgd1qmito.jpg)
SDH + COX stain
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Muscle fibers with
COX stain: Reduced
SDH stain: Increased
![](../pics/biopsy/lgd/plectin/lgd1qsdh.jpg) SDH stain
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Mitochondrial Pathology
Elongated mitochondria
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Muscle autoantibodies
4/21/2018