Phosphoglycerate Mutase deficiency (GSD 10)
Trp78* mutation
 H&E stain |
Size: Normal
Contain: Tubular aggregates
 H&E stain |
Pink-stained regions on H&E stain
Internal or sub-sarcolemmal
 H&E stain |
Tubular aggregates: Red stained
 Gomori trichrome stain |
 VvG stain |
Dark stained
Irregular shapes
 VvG stain |
 VvG stain |
Dark stained
Irregular shapes
 VvG stain |
 NADH stain |
NADH stained: Composed of SR-like tubules
Irregular shapes
May be small or large
May have several in one muscle fiber
 NADH stain |
 NADH stain |
 AMPDA stain |
Contain AMPDA
 AMPDA stain |
Phosphoglycerate Mutase deficiency
Glycogen: May be increased in muscle fibers
Tubular aggregates: Can stain for PAS
 PAS stain |
 Sudan black stain |
 ATPase pH 4.3 stain |
Glycogen: Membrane bound & Free in cytoplasm
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7/2/2016