Kearns-Sayre PEO Ultrastructure Also see Mitochondrial disease ultrastructure |
Muscle Fiber Morphology Scattered muscle fibers with Varied size Irregular internal architecture Large nuclei Basophilic cytoplasm Endomysial connective tissue: Normal ![]() H&E stain |
![]() H&E stain |
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Ragged red muscle fibers Mitochondrial proliferation: Varied Degrees Muscle fiber cytoplasm Entirely replaced by mitochondria (Red) in some segments Coarse internal architecture in other segments |
![]() Gomori trichrome |
![]() Gomori trichrome |
![]() SDH stain Mitochondrial proliferation: SDH+ muscle fibers with variably increased degrees of staining ![]() SDH stain |
![]() COX stain Cytochrome oxidase: Scattered muscle fibers with reduced or increased staining |
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![]() COX stain |
![]() COX stain |
![]() Sudan black |
Lipid: Increased size of lipid droplets in scattered muscle fibers |
![]() Sudan black |
![]() H&E |
Muscle fiber size: Mild variation Basophilic mucle fibers: Occasional; Intermediate sized |
![]() H&E |
![]() Gomori trichrome |
Ragged red muscle fibers Mitochondrial proliferation: Mild Muscle fiber cytoplasm Coarse internal architecture in some segments |
![]() Gomori trichrome |
![]() SDH stain | |
Mitochondrial proliferation SDH+ muscle fibers with variably increased degrees of staining ![]() SDH stain |
![]() SDH stain |
![]() COX |
Cytochrome oxidase: Scattered muscle fibers with reduced staining |
![]() COX |
![]() Sudan |
Scattered muscle fibers with increased staining |
![]() ATPase pH 9.4 |
Fiber types: Type 2 predominance; Smallest fibers are type 1; No 2 C fibers |
![]() ATPase pH 4.3 |
![]() From: Robert Schmidt |
![]() From: Robert Schmidt |
![]() From: Robert Schmidt |
![]() |
![]() From: Robert Schmidt |
![]() From: Robert Schmidt |
![]() From: Robert Schmidt |