HNRNPA1 Myopathy: IBMPFD3
|
Aggregates Myopathy Vacuoles |
 H&E stain |
Muscle fibers
Sizes: Varied
Small fibers
Round > Elongated
May occur in clusters
Large fibers: Hypertrophy
Internal nuclei
Endomysial connective tissue: Increased with disease progression
 H&E stain |
 NADH stain |
Muscle fibers
Sizes: Varied
Small fibers: Dark stained
Large fibers: Central pallor
 NADH stain |
 Gomori trichrome stain |
Muscle fibers
Sizes: Varied
Internal nuclei
Vacuoles: Irregular shapes; May contain red debris
 Acid phosphatase stain |
Acid phosphatase stains cytoplasm or cytoplasmic granules in some fibers
HNRNPA1: Vacuoles
 H&E stain |
Muscle fibers
Sizes: Varied
Vacuoles: Small & Large sizes; Irregular shapes
 H&E stain |
 Gomori trichrome stain |
Shapes: Irregular
Contents: Amorphous debris
 Congo red stain |
HNRNPA1: Aggregates in muscle fibers
 AMPDA stain |
Distribution
Scattered in muscle fiber
May be near edges of vacuoles
Commonly stain for AMPDA
 AMPDA stain |
 AMPDA stain |
Cytoplasmic bodies: Many in one muscle fiber
 Gomori trichrome stain |
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8/27/2025