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Diabetes: Small Vessel/Capillary Pathology

Muscle Nerve

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Diabetes Muscle: Endomysial Capillaries

Control

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Endomysial Capillary: Damaged
  Wall: Irregular Basal lamina:
  Endothelial cells: Lost in some regions

From: R Schmidt

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Endomysial Capillary
  Wall: Basal lamina
    Thick
    Homogeneous structure
    Contains small cell processes
  Endothelial cells: Thin rim around lumen

From: R Schmidt

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Endomysial Capillary
  Wall: Basal lamina
    Thick
    Structure: Homogeneous or Mildly fragmented

From: R Schmidt

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Endomysial Capillary
  Wall
    Basal lamina: Normal thickness & structure
  Endothelial cells: Some are small & have pale cytoplasm

From: R Schmidt

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Diabetes Nerve: Endoneurial Microvessels

Control Vessels

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Endoneurial Microvessels: Mild pathology
  Wall
    Basal Lamina Layers: Increased numbers
    Pericyte process: Between Endothelial cells & Connective tissue layers
  Endothelial cells: Large
  Lumen: Small

From: R Schmidt

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Endoneurial Microvessels: Mild pathology
  Wall
    Basal Lamina Layers: Increased numbers; Collagen may be present between layers
    Pericyte processes & Nucleus: Between Endothelial cells & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent

From: R Schmidt

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Endoneurial Microvessels: Mild pathology
  Wall
    Basal Lamina Layers: Increased numbers; Collagen may be present between layers
    Cell processes & Nuclei: Between Endothelial cells & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent or Small

From: R Schmidt

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Endoneurial Microvessels: Mild pathology
  Wall
    Basal Lamina Layers: Increased numbers; Collagen may be present between layers
    Cell processes: Between Endothelial cells & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent
  Fibroblast processes: Around outside of vessel

From: R Schmidt

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Endoneurial Microvessels: Moderate pathology
  Wall
    Basal Lamina Layers: Increased numbers; Collagen may be present between layers
    Cell processes: Between Endothelial cells & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent
  Fibroblast processes: Thin; Around outside of vessel

From: R Schmidt

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Endoneurial Microvessels: Moderate pathology
  Wall
    Basal Lamina Layers: Increased numbers; Collagen may be present between layers
    Cell processes: Between Endothelial cells & Connective tissue layers
  Endothelial cells: Large
  Lumen: Small
  Fibroblast processes: Around outside of vessel

From: R Schmidt

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Endoneurial Microvessels: Moderate pathology
  Wall
    Basal Lamina Layers: Increased numbers; Collagen may be present between layers
    Cell processes: Between Endothelial cells & Connective tissue layers
  Endothelial cells: Large
  Lumen: Small
  Fibroblast processes: Around outside of vessel

From: R Schmidt

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Endoneurial Microvessels: Moderately severe pathology
  Wall
    Basal Lamina: Scattered; Collagen & Fibrils are major component of wall
    Cell processes: Between Endothelial cell & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent
  Fibroblast processes: Thin; Around outside of vessel

From: R Schmidt

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Endoneurial Microvessels: Moderately severe pathology
  Wall: Thick
    Basal Lamina: Scattered
    Collagen & Fibrils: Major component of wall; Less dense in outer regions of wall
    Cell processes: Between Endothelial cell & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent
  Fibroblast processes: Thin; Around outside of vessel

From: R Schmidt

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Endoneurial Microvessels: Moderately severe pathology
  Wall: Thick; Varied pathology in different regions
    Basal Lamina: Scattered or Increased layers
    Collagen & Fibrils: Major component of wall; Less dense in outer regions of wall
    Cell processes: Between Endothelial cell & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent
  Fibroblast processes: Thin; Around outside of vessel

From: R Schmidt

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Endoneurial Microvessels: Moderately severe pathology
  Wall: Very Thick
    Basal Lamina: Scattered
    Collagen & Fibrils: Major component of wall; Less dense in outer regions of wall
    Cell processes: Between Endothelial cell & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent

From: R Schmidt

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Endoneurial Microvessels: Moderately severe pathology
  Wall: Very Thick
    Basal Lamina: Linear in wall
    Collagen & Fibrils: Major component of wall; Less dense in outer regions of wall
    Cell processes: Between Endothelial cell & Connective tissue layers
  Endothelial cells: Large
  Lumen: Absent
  Fibroblast processes: Thin; Around outside of vessel

From: R Schmidt

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Endoneurial Microvessels: Severe pathology
  Wall: Thick
    Basal Lamina: Linear in wall
    Collagen & Fibrils: Major component of wall; Less dense in outer regions of wall
    Cell processes: Within Connective tissue layers
  Endothelial cells: Dark stained; Damaged cytoplasm
  Lumen: Absent

From: R Schmidt

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5/26/2026