BULBOSPINAL MUSCULAR ATROPHY
Patterns of Pathology: Muscle
H & E stain |
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Muscle Fibers Sizes Hypertrophic Small: Angular or Rounded Grouped or Individual Pyknotic nuclear clumps (Large) Internal architecture Partially fused (Split) Internal nuclei Damage Necrosis: Scattered large fibers Regeneration: Clustered immature fibers |
 VvG stain |
 H & E stain |
 VvG stain |
 H & E stain |
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 |
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Internal nuclei
Partial, or incomplete, fusion
Hypertrophy
Pyknotic nuclear clumps
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Muscle fibers: Small & Angular, or Pyknotic nuclear clumps |
|
 H & E stain |
 Esterase stain |
Muscle fibers: Grouped atrophy
 H&E stain |
 H&E stain |
 H&E stain |
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Grouped atrophy Smaller fibers may be rounded or angular Large muscle fibers are hypertrophied | ||
 VvG stain | ||
 Gomori trichrome stain |
 Esterase stain |
Muscle fibers: Internal architecture
 NADH stain |
 NADH stain |
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Some small fibers are darkly stained Large muscle fibers Coarse internal architecture; Pale centers "Splitting" (Partial fusion)(Below) | |
 NADH stain | |
 NADH stain |
Muscle: Fiber types
 ATPase, pH 9.4 |
 ATPase, pH 9.4 |
 ATPase pH 4.3 stain |
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Large muscle fibers: Type 1 predominance Small muscle fibers: Either type 1 or 2 Grouped atrophy: Small regions; Mixed fiber types |
 ATPase pH 9.4 stain |
Neuronal Intranuclear Aggregates
 From Mei Li MD Androgen Receptor in Motor Neuron
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 From Mei Li MD Polyglutamine in Motor Neuron
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5/24/2019