Antibody & Biopsy
Fludarabine Infusion Protocol
Possible severe side effects
Bone marrow suppression: Anemia, Thrombocytopenia Neutropenia
Patient is admitted for treatment by staff.
Vital signs: Obtain on initial evaluation and Hourly during infusion
Height and weight: Measure for Fludarabine dose calculation.
Patient is evaluated by a study physician: Obtain
Pertinent physical exam
Quantitative dynamometry: On first and last visit; Performed by Dr Pestronk
Blood: CBC and electrolytes, glucose, and creatinine (BMP)
First and last admissions: Blood is also drawn for
Antibody titers to GM1 ganglioside or MAG: 2 red top tubes to
Room 404 IWJ
Immunocompetency panel: Send for CD3, CD19
Start IV heparin lock
Start normal saline at 100 cc/hr
Run saline at keep vein open (kvo) rate during infusion
: 5 consecutive days each month x 6 months
Fludarabine dose: 25 mg/M
. Calculate absolute dose to be administered.
Fludarabine Infusion: Over 30 minutes
Patients may take all regular medicines while in hospital.
Problems: Contact the Neuromuscular fellow immediately.
A fellow is available 24 hours a day
Phone #: 388-6138
Notify fellow for
Temp > 38.0
Respiratory symptoms: Shortness of breath must be reported immediately.
Encephalopathy: Mental status change; Visual loss
Activity while in hospital: Patient may be up ad lib
Patient should be sent home on their regular medicines
Follow-up: 2 months after final infusion in the Neuromuscular clinic.
Questions or problems: Patient should call Neuromuscular office at 314-362-6981.
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