Neuromuscular

TNF receptor-associated periodic syndrome (TRAPS)

PERIMYSIAL PATHOLOGY



H&E stain

Avascular perimysium: Widened; Contains many large cells, probably histiocytes


H&E stain

Vascular perimysium: Widened; Increased mononuclear cellularity

Gomori trichrome stain<

Vascular perimysium: Widened; Increased mononuclear cellularity


H&E stain<

Neovascularization: Small, nascent vessels surround an intermediate-sized perimysial vessel


H&E stain<

Mononuclear cell inflammation surrounds an Intermediae sized perimysial vessel


Alkaline phosphatase stain<

Alkaline phosphatase stains Perimysial connective tissue & Endomysial capillaries


Alkaline phosphatase stain<

Alkaline phosphatase: Dark staibning of perimysial connective tissue


Alkaline phosphatase stain<

Acid phosphatase: Cellularity through the perimysium, and extending into endomysial regions,
  but not concentrated near vessels


Alkaline phosphatase stain<

Acid phosphatase: Cellularity in the thickened epimysial connective tissue surrounding muscle



Peroxidase positive perimysial cells


VvG stain

Abnormal vessel structure with reduced elastin fibrils

Return to Inflammatory myopathies
Return to TRAPS

1/24/2013