Neuromas
 H&E stain Fascicles with varied size and orientations  H&E stain |
 Gomori trichrome stain Fascicles with varied size and orientations  Gomori trichrome stain Neuroma: Multiple small fascicles containing thinly myelinated axons  VvG stain |
 Neurofilament stain |
Contain myelinated & unmyelinated axons
 Neurofilament stain |
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Varied sizes & orientations of axon clusters (fascicles)
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Neuroma
Axons in fascicles tend to be thinly myelinated for their size
Small fascicles contain 1 to 30 myelinated axons
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Neuroma
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Varied numbers of myelinated and non-myelinated axons in fascicles
Varied numbers of axons in fascicles
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Neuroma
Several small fascicles separated by connective tissue
Each fascicle is surrounded by perineurium, 1 or several layers
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Neuroma originating from normal fascicle
Normal nerve fascicle (Left); Fascicles with varied size and orientations (Right)
 VvG stain  VvG stain  Gomori trichrome stain |
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Neuroma Small fascicles containing 1 or 2 thinly myelinated axons (Top) Fascicle with normal organization (Bottom left)  Toluidine blue stain Small fascicles containing thinly myelinated axons 
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2/13/2017