 H & E stain |
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Myopathy: Mild active & chronic changes Necrosis & Regeneration: Scattered Fiber size: Varied Small fibers: Rounded Endomysial connective tissue: Normal or Slightly increased Internal nuclei: Some fibers |
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 ATPase pH 9.4 Type I fiber predominance |
 ATPase pH 4.3 Scattered 2C fibers |
 NADH stain Type I fiber predominance; Necrotic fiber (arrow) |
 α Dystroglycan FKRP mutations: Absent α-Dystroglycan around muscle fibers |
 α Dystroglycan Control muscle: Normal α-Dystroglycan around muscle fibers |
 Desmin stain Desmin stains cytoplasm in small regenerating fibers |
 MHC Class I stain MHC-I is abnormally present on clusters of muscle fibers |