ANA Patterns

Anti-Nuclear (ANA; HEp-2 IFA) & Cytoplasmic Antibody: Staining Patterns

	ANA Pattern	Antigens	Diagnosis	Images: Link
Nuclear	Homogeneous	dsDNA Nucleosomes Histones	SLE, Drug-induced Hepatitis Juvenile arthritis	HEp-2 cell IIF Link
	Speckled	Scl70 Sm U1RNP U4/U6RNP U5RNP U11/12RNP RNA Pol III Ku antibody RuvBl 1/2	SLE SSc MCTD Sjögren	HEp-2 cell IIF Link
	Fine Speckled	SS-A/Ro SS-B/La Mi-2 TIF1-γ & -β Ku	Systemic Sclerosis Dermatomyopathy
	Nucleolar	PM/Scl Th/To Fibrillarin	SSc BCIM	HEp-2 cell IIF Link
	Dots	SMN p80-coilin	None
	Multiple Dots	Sp-100 PML proteins SUMO (SAE) MJ/NXP-2	Dermatomyopathy	Link
	Centromere	Centromere CENP-B	SSc: Limited Cutaneous/CREST	Link
	Peripheral	RNP Sm	Systemic Sclerosis	Link
	Neuronal	Hu	Sensory Neuronopathy Limbic enephalitis Ataxia Autonomic
Cytoplasmic	Fine Speckled	RuvBL 1/2 eiF2b PL7 PL12 RibP	SLE IMPP
	Speckled	Jo-1	IMPP
	Granular	HMGCR	Muscle Fiber Necrosis/IMPP
None		SRP	Immune Myopathy

Anti-Hu antibodies: Stain neuronal nuclei; Nucleoli not stained