Neuromuscular

TNF Receptor-Associated Periodic Syndrome (TRAPS)



H&E stain

PERIMYSIAL PATHOLOGY


H&E stain

Avascular perimysium: Widened; Contains many histiocytes


H&E stain

Vascular perimysium: Widened; Increased mononuclear cellularity

Gomori trichrome stain

Vascular perimysium: Widened; Increased mononuclear cellularity


H&E stain
Neovascularization: Small, nascent vessels surround abnormal Intermediate-sized perimysial vessels

Gomori trichrome stain

Neovascularization
  Many small capillaries in perimysial connective tissue: Endothelium is stained by UEAI lectin

UEA1 stain


H&E stain

Mononuclear cell inflammation surrounds an Intermediae sized perimysial vessel


Alkaline phosphatase stain
Alkaline phosphatase stains Perimysial connective tissue & Endomysial capillaries


Alkaline phosphatase stain

Alkaline phosphatase: Dark staibning of perimysial connective tissue


Alkaline phosphatase stain<

Acid phosphatase: Cellularity through the perimysium, and extending into endomysial regions,
  but not concentrated near vessels


Alkaline phosphatase stain<

Acid phosphatase: Histiocytes in thickened epimysial connective tissue surrounding muscle



Peroxidase positive perimysial cells


VvG stain

Abnormal vessel structure with reduced elastin fibrils

Return to Inflammatory myopathies
Return to TRAPS

10/15/2021