Sporadic, Late Onset Nemaline Myopathy (SLONM)
Muscle features
- Muscle fiber size: Varied
- Myonuclei: Large; May be clumped
- Internal architecture
- Fiber types
- Type I: Predominance
- Type 2: Small; Many 2C
SLONM: Myopathy
Fiber size: Varied
Endomysial connective tissue: Increased
![](../pics/biopsy/rods/slonm/slonmhelp.jpg)
H&E stain
|
![](../pics/biopsy/rods/slonm/slonmhemp.jpg)
H&E stain
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SLONM: Myonuclei
Large
May be clumped
![](../pics/biopsy/rods/slonm/slonmhehp2.jpg)
H&E stain
|
![](../pics/biopsy/rods/slonm/slonmnuccrhp2.jpg)
Congo red stain
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SLONM: Myonuclei
Large
Clumped in some fibers
![](../pics/biopsy/rods/slonm/slonmnuccrhp.jpg)
Congo red stain
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![](../pics/biopsy/rods/slonm/slonmnucgthp2.jpg)
Gomori trichrome stain
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SLONM: Myonuclei
Large
Some fibers: Clumped or Occupy entire myofiber cytoplasm
![](../pics/biopsy/rods/slonm/slonmnucgthp.jpg)
Gomori trichrome stain
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SLONM: Muscle Fiber Internal Architecture
![](../pics/biopsy/rods/slonm/slonmvvgmp.jpg)
VvG stain
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Myofiber cytoplasm
Irregular, Coarse Internal architecture
Internal nuclei
![](../pics/biopsy/rods/slonm/slonmvvgmp2.jpg)
VvG stain
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![](../pics/biopsy/rods/slonm/slonmvvgmp3.jpg)
VvG stain
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Myofiber cytoplasm
Irregular, Coarse Internal architecture
Internal nuclei
![](../pics/biopsy/rods/slonm/slonmnadh.jpg)
NADH stain
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SLONM: Nemaline Rods
![](../pics/biopsy/rods/slonm/slonmgthp6.jpg)
Gomori trichrome stain
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Nemaline Rods
Size: Very small
Distribution in fiber: Diffuse; Often in large of cytoplasm
May be more common in small fibers
![](../pics/biopsy/rods/slonm/slonmgtmp.jpg)
Gomori trichrome stain
|
![](../pics/biopsy/rods/slonm/slonmgthp7.jpg)
Gomori trichrome stain
|
Nemaline Rods
Size: Very small
Distribution in fiber: Diffuse; Often in large of cytoplasm
May be more common in small fibers
![](../pics/biopsy/rods/slonm/slonmgthp2.jpg)
Gomori trichrome stain
|
SLONM: Clustered Rod-like Material
![](../pics/biopsy/rods/slonm/slonmgthp4.jpg)
Gomori trichrome stain
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Nemaline Rods
Size: Very small
Distribution in fiber: Diffuse; Often in large of cytoplasm
May be more common in small fibers
![](../pics/biopsy/rods/slonm/slonmgthp3.jpg)
Gomori trichrome stain
|
![](../pics/biopsy/rods/slonm/slonmgthp5.jpg)
Gomori trichrome stain
|
Nemaline Rods
Size: Very small
Distribution in fiber: Diffuse; Often in large of cytoplasm
May be more common in small fibers
![](../pics/biopsy/rods/slonm/slonmgthp1.jpg)
Gomori trichrome stain
|
SLONM: AMPDA aggregates
![](../pics/biopsy/rods/slonm/slonmampda.jpg)
AMPDA stain
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SLONM: Fiber types
Type I predominance
Small fibers mostly 2C
![](../pics/biopsy/rods/slonm/slonmatp43.jpg)
ATPase pH 4.3 stain
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Sporadic, Late Onset Nemaline Myopathy (SLONM)
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3/15/2024