---

Lipid Storage Myopathy: Sertraline

---

H&E stain

Muscle Fibers
  Lipid droplets
    Multiple clear round regions in individual muscle fibers
    Frequency: 30% to 50% of muscle fibers
  Sizes: Mildly varied

Gomori trichrome stain

H&E stain

Muscle Fibers
  Lipid droplets
    Multiple clear round regions in individual muscle fibers
    Frequency: 30% to 50% of muscle fibers
  Sizes: Mildly varied

---

Gomori trichrome stain

Lipid storage
  Some muscle fibers may have large lipid droplets of varied size
  Lipid droplets stain for Oil Red O and Sudan black

Oil red O stain

---

Lipid Disorders: NADH stain
  Often punctate within muscle fibers

NADH stain

---

MHC1 stain

Lipid Disorders: Capillaries
  Number & Size: Increased

MHC1 stain

Lipid Disorders: Capillaries
  Number & Size: Increased
Muscle fibers: May have midly increased MHC-I expressed in cytoplasm

MHC1 stain

---

Toluidine blue stain

Lipid Storage Disrders: Toluidine blue stain
  Muscle fibers: Multiple clear & Dark Lipid droplets

Toluidine blue stain

Toluidine blue stain

---

Sertaline Lipid Myopathy
  Lipid droplets: Dark stained; Scattered in muscle fibers
  Mitochondria: Increased numbers scattered in muslce fibers

---

Return to: Sertraline
Return to: Neuromuscular Home Page

8/29/2025