Neuromuscular

Neuromas


H&E stain
Fascicles with varied size and orientations

H&E stain

Gomori trichrome stain
Fascicles with varied size and orientations

Gomori trichrome stain
Neuroma: Multiple small fascicles containing thinly myelinated axons

VvG stain

Neurofilament stain
Neuroma: Small fascicles in epineurium
  Contain myelinated & unmyelinated axons

Neurofilament stain
Neuroma
  Varied sizes & orientations of axon clusters (fascicles)
Neuroma
  Axons in fascicles tend to be thinly myelinated for their size
  Small fascicles contain 1 to 30 myelinated axons
Neuroma
Neuroma
  Varied numbers of myelinated and non-myelinated axons in fascicles
  Varied numbers of axons in fascicles
Neuroma
  Several small fascicles separated by connective tissue
  Each fascicle is surrounded by perineurium, 1 or several layers
Neuroma originating from normal fascicle
Normal nerve fascicle (Left); Fascicles with varied size and orientations (Right)

VvG stain

VvG stain

Gomori trichrome stain
Neuroma
Small fascicles containing 1 or 2 thinly myelinated axons (Top)
Fascicle with normal organization (Bottom left)

Toluidine blue stain
Small fascicles containing thinly myelinated axons
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2/13/2017