HMSN with Minifascicles
![](../pics/biopsy/nerve/minifasc/minifasciclescrlp.jpg)
Congo red stain
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Minifascicles: Sural nerve with many small fascicles
Age: 33 weeks gestation + 10 weeks post-partum
![](../pics/biopsy/nerve/minifasc/minifasciclesgtlp.jpg)
Gomori trichrome stain
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![](../pics/biopsy/nerve/minifasc/minifascicleshe.jpg)
H&E stain
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![](../pics/biopsy/nerve/minifasc/minifasciclesgtmp.jpg)
Gomori trichrome stain
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Sural nerve: Fascicles
Varied size from tiny to intermediate sized
![](../pics/biopsy/nerve/minifasc/minifasciclesvvghp.jpg)
VvG stain
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![](../pics/biopsy/nerve/minifasc/minifasciclesnfg.jpg)
Neurofilament stain
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Sural nerve: Axons
Small & Larger axons in all fascicles
Small axons have associated non-myelinating Schwann cells (Yellow & Red (Below))
![](../pics/biopsy/nerve/minifasc/minifascicsuralnfgncamr.jpg)
Neurofilament + NCAM stain
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![](../pics/biopsy/nerve/minifasc/minifasciclesnf.jpg)
Neurofilament stain
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![](../pics/biopsy/nerve/minifasc/minifasciclesncam.jpg)
NCAM stain
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![](../pics/biopsy/nerve/minifasc/minifasciclehp2.jpg)
Toluidine blue stain; From K Sugie
- Multiple small fascicles in single sural nerve
- Reduced numbers of larger myelinated axons
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Minifascicles: Sciatic Nerve
![](../pics/biopsy/nerve/minifasc/minfassciattblp.jpg)
Toluidine blue stain
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Sciatic nerve
4 to 5 fold increase in numbers of fascicles
Sciatic nerve
Many larger axons have thin, or no, myelin
Axon populations vary among fascicles
![](../pics/biopsy/nerve/minifasc/minfassciattbhp.jpg)
Toluidine blue stain
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HMSN with Minifascicles
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4/19/2020