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HMSN with Minifascicles

Sural nerve Sciatic nerve

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Congo red stain

Minifascicles: Sural nerve with many small fascicles
  Age: 33 weeks gestation + 10 weeks post-partum

Gomori trichrome stain

H&E stain

Gomori trichrome stain

Sural nerve: Fascicles
  Varied size from tiny to intermediate sized

VvG stain

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Neurofilament stain

Sural nerve: Axons
  Small & Larger axons in all fascicles
Small axons have associated non-myelinating Schwann cells (Yellow & Red (Below))

Neurofilament + NCAM stain

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Neurofilament stain

NCAM stain

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Toluidine blue stain; From K Sugie Multiple small fascicles in single sural nerve Reduced numbers of larger myelinated axons

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Minifascicles: Sciatic Nerve

Toluidine blue stain

Sciatic nerve
  4 to 5 fold increase in numbers of fascicles

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Sciatic nerve
  Many larger axons have thin, or no, myelin
  Axon populations vary among fascicles

Toluidine blue stain

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4/19/2020