HMSN with Minifascicles

Congo red stain
Minifascicles: Sural nerve with many small fascicles
  Age: 33 weeks gestation + 10 weeks post-partum

Gomori trichrome stain

H&E stain

Gomori trichrome stain
Sural nerve: Fascicles
  Varied size from tiny to intermediate sized

VvG stain

Sural nerve: Axons
  Small axons in all fascicles

Neurofilament stain

Neurofilament stain

NCAM stain

Toluidine blue stain; From K Sugie
  • Multiple small fascicles in single sural nerve
  • Loss of myelinated axons

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