Neuromuscular

LGMD 2C: γ-Sarcoglycan Deficiency


H & E stain

Muscle fiber necrosis & regeneration
Increased endomysial connective tissue
Varied muscle fiber size


H & E stain

GT stain
Increased endomysial connective tissue
Varied muscle fiber size


ATPase pH 4.3 stain

Alkaline phosphatase stain
Many immature muscle fibers
Intermediate staining on ATPase pH 4.3
Positive staining on alkaline phosphatase


Acid phosphatase stain

Necrotic muscle fibers
Pale staining
Contain Acid phosphatase positive phagocytic cells (macrophages)


γ-Sarcoglycan stain

Reduced γ-sarcoglycan staining

γ-Sarcoglycan stain

Control muscle: Normal γ-sarcoglycan staining

Return to Neuromuscular
Return to LGMD 2C, γ-Sarcoglycan Deficiency

10/31/2003