Myopathy with Sarcoplasmic pads & Grouped muscle fiber atrophy
![](../pics/biopsy/muscle/filc/filc1vvglp2.jpg)
VvG stain
|
Myopathy
Fiber sizes: Varied
Small muscle fibers: Present in clusters
![](../pics/biopsy/muscle/filc/filc1nadhlp1.jpg)
NADH stain
|
![](../pics/biopsy/muscle/filc/filc1hemp.jpg)
H&E stain
|
Myopathy
Varied pathology in different regions
Some areas have many small fibers
Small fibers have dark staining and
large nuclei
Other regions only have a few intermediate sized fibers
![](../pics/biopsy/muscle/filc/filc1hemp2.jpg)
H&E stain
|
![](../pics/biopsy/muscle/filc/filc1vvghp.jpg)
VvG stain
|
Muscle fiber internal architecture
Sarcoplasmic pads around small fibers
Other small & Large fibers have irregular internal archjitecture
![](../pics/biopsy/muscle/filc/filc1vvghp4.jpg)
VvG stain
|
Muscle fiber internal architecture
Sarcoplasmic pads around small fibers
Other small & Large fibers have irregular internal archjitecture
Internal nuclei: Present in some muscle fibers
![](../pics/biopsy/muscle/filc/filc1vvghp6.jpg)
VvG stain
|
![](../pics/biopsy/muscle/filc/filc1gtmp1.jpg)
Gomori trichrome stain
|
Myopathy
Fiber sizes: Varied
Small fibers: Dark stained
Endomysial connective tissue: Increased between muscle fibers
![](../pics/biopsy/muscle/filc/filc1gthp1.jpg)
Gomori trichrome stain
|
![](../pics/biopsy/muscle/filc/filc1nadhhp1.jpg)
NADH stain
|
Muscle fiber internal architecture
Sarcoplasmic pads around small fibers
Other small muscle fibers have irregular internal archjitecture
![](../pics/biopsy/muscle/filc/filc1nadhhp2.jpg)
NADH stain
|
![](../pics/biopsy/muscle/filc/filccoxmp.jpg)
COX stain
|
Mitochondria
Abundant in sarcoplasmic pads
![](../pics/biopsy/muscle/filc/filccoxhp.jpg)
COX stain
|
Mitochondria
Abundant in sarcoplasmic pads
![](../pics/biopsy/muscle/filc/filcsdhhp.jpg)
SDH stain
|
![](../pics/biopsy/muscle/filc/filcdesmin.jpg)
Desmin stain
|
Desmin
Increased in cytoplasm of small muscle fibers
![](../pics/biopsy/muscle/filc/filcdys1.jpg)
Dys1 stain
|
Dystrophin
Small fibers have moderately thick sarcolemma
![](../pics/biopsy/muscle/filc/filccrhp.jpg)
Congo red stain
|
Myonuclei
Large & irregular shapes in small fibers
![](../pics/biopsy/muscle/filc/filccrhp2.jpg)
Congo red stain
|
![](../pics/biopsy/muscle/filc/filcemerinhp.jpg)
Emerin stain
|
Myonuclei
Large & irregular shapes in small fibers
![](../pics/biopsy/muscle/filc/filcatp94.jpg)
ATPase pH 9.4 stain
|
fiber types
Small fibers: Mixed types; Many 2C
No fiber type grouping
![](../pics/biopsy/muscle/filc/filcatp43.jpg)
ATPase pH 4.3 stain
|
Return to:
Filamin C
Return to:
Neuromuscular Home Page
4/29/2024