Muscle Pathology
Gomori trichrome stain
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Muscle Fiber Morphology
Mildly irregular internal architecture, especially in darker stained fibers
VvG stain
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Muscle Fiber Morphology
Mildly irregular internal architecture, with linearization in paler stained fibers
NADH stain
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Congo red stain
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Myonuclei
Size: Often large
Shapes: Irregular
Congo red stain
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Acid phosphatase stain
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Acid phosphatase + Granules
Several large, dark granules present in most muscle fibers
Acid phosphatase stain
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Acid phosphatase stain
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Acid phosphatase + Granules
Granules present in vessel walls
Acid phosphatase stain
|
Acid phosphatase stain
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Acid phosphatase + Granules
Granules present in vessel walls
Acid phosphatase stain
|
Acid phosphatase stain
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LAMP2 stain
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Batten disease muscle
LAMP2 granules are prominent in muscle fiber cytoplasm
LAMP2 stain
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Control muscle
LAMP2 granules are not prominent in muscle fiber cytoplasm
LAMP2 stain
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COX stain
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Mitochondrial stains
No mitochondrial pathology
SDH stain
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Batten disease: Nerve pathology
H&E stain
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Nerve morphology
Normal endoneurium, perineurium & epineurium
Gomori trichrome stain
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Myelinated axons
Mild loss
VvG stain
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Small unmyelinated axons
Normal numbers
Neurofilament stain
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Acid phosphatase stain
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Acid phosphatase + Granules
Scattered in endoneurium
Present in walls of epineurial vessels
Acid phosphatase stain
|
Acid phosphatase stain
|
Acid phosphatase + Granules
Present in walls of epineurial vessels
Acid phosphatase stain
|
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Neuromuscular Home Page
4/8/2023