Muscle Pathology

Gomori trichrome stain
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Muscle Fiber Morphology
Mildly irregular internal architecture, especially in darker stained fibers

VvG stain
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Muscle Fiber Morphology
Mildly irregular internal architecture, with linearization in paler stained fibers

NADH stain
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Congo red stain
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Myonuclei
Size: Often large
Shapes: Irregular

Congo red stain
|

Acid phosphatase stain
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Acid phosphatase + Granules
Several large, dark granules present in most muscle fibers

Acid phosphatase stain
|

Acid phosphatase stain
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Acid phosphatase + Granules
Granules present in vessel walls

Acid phosphatase stain
|

Acid phosphatase stain
|
Acid phosphatase + Granules
Granules present in vessel walls

Acid phosphatase stain
|

Acid phosphatase stain
|

LAMP2 stain
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Batten disease muscle
LAMP2 granules are prominent in muscle fiber cytoplasm

LAMP2 stain
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Control muscle
LAMP2 granules are not prominent in muscle fiber cytoplasm

LAMP2 stain
|

COX stain
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Mitochondrial stains
No mitochondrial pathology

SDH stain
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Batten disease: Nerve pathology

H&E stain
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Nerve morphology
Normal endoneurium, perineurium & epineurium

Gomori trichrome stain
|
Myelinated axons
Mild loss

VvG stain
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Small unmyelinated axons
Normal numbers

Neurofilament stain
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Acid phosphatase stain
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Acid phosphatase + Granules
Scattered in endoneurium
Present in walls of epineurial vessels

Acid phosphatase stain
|

Acid phosphatase stain
|
Acid phosphatase + Granules
Present in walls of epineurial vessels

Acid phosphatase stain
|
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Neuromuscular Home Page
4/8/2023