Intravascular Lymphoma (Angiotropic B-cell)
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Brain Muscle |
IV Lymphoma: Muscle
 H&E stain |
Cells aggregated in regions of vessels, often adhering to wall
 Gomori trichrome stain |
 H&E stain  Lymphoma cells in vessels |
 H&E stain |
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 H&E stain |
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Large, pleomorphic neoplastic B-cells: In lumens of small & intermediate sized vessels 
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 H&E stain | ||
 H&E stain |
 Congo red stain |
 NADH stain Hemosiderin (Brown) in endomysium
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 Acid phosphatase stain Histiocytic cells in vessel walls
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 Intravascular cells in endoneurium stain for Leukocyte common antigen  Vessel walls stain for Ulex lectin |
Intravascular lymphoma cells
Mild staining with acid phosphatase
 Acid phosphatase stain |
 CD20 stain From: A Perry CD20+ cells in vessels & connective tissue
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 CD20 stain CD20+ cells in vessel walls
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 CD20 stain CD20+ cells in vessel lumens |
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 CD20 stain |
 CD20 stain |
Intravascular B-cell lymphoma cells stain for: MUM-1 & BCL6
 MUM-1 stain |
 BCL6 stain |
Intravascular Lymphoma, B-cell: Brain
 H&E stain From: R Bucelli |
Intravascular: Mostly B-cells (Right & Below)
Vessel wall: CD3 cells & Histiocytes
 H&E stain From: R Bucelli |
Intravascular: Mostly B-cells (Above)
Vessel wall: CD3 cells & Histiocytes (Below)
 H&E stain From: R Bucelli |
 CD20 stain From: R Bucelli |
Intravascular: Mostly CD20+ B-cells (Above & Below)
 CD20 stain From: R Bucelli |
 CD3 stain From: R Bucelli |
Vessel wall: Mostly CD3+ Lymphocytes (Above & Below)
 CD3 stain From: R Bucelli |
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2/8/2021