ACOX1: Mitchell syndrome

H&E stain
Nerve Morphology: Normal Perineurium, Epineurium & Vessels

Gomori trichrome stain
Axon loss: Varied within some fasicles

VvG stain

Neurofilament stain
Large Axon loss: Small axons relatively preserved

Neurofilament stain

NCAM stain
Non-myelinating Schwnn cells: Present in clusters around small axons

VvG stain
Epineurial artery: Fibrils mildly reduced

Myelinated axons: Morphology & Pathology

Toluidine blue stain
Myelinated Axons
  Myelin sheaths: Normal thickness
  Axon numbers: Loss of large & small myelinated axons
  Wallerian degeneration

Toluidine blue stain
Wallerian Degeneration
  Scattered cells containing myelin debris & lipid droplets

Toluidine blue stain

Myelin debris in phagocytic Schwann cells

Lipid droplets & Debris in Endoneurial macrophage

Toluidine blue stain
Myelin sheath: Irregular folding around some axons

Neurofilament (Green) + P0 (Red) stains
Myelinated axons (Yellow): Normal to reduced numbers
  Acute axon loss: Some P0 regions (Red) with no axons

Neurofilament (Green) + MBP (Red) stains

Axon loss: Acute
  MBP regions (Red) with no associated axon

NCAM (Green) + P0 (Red) stains
Axon loss: Chronic
  Schwann cells, scattered, (Yellow) that co-stain for both NCAM & P0
Return to Neuromuscular Home Page