|
DM1: Chronic changes DM1: Mild changes DM2 |
Myotonic dystrophy (DM1): Chronic changes |
 H&E stain |
|
 Congo red stain |
|
 Gomori trichrome stain |
 NADH stain |
|
Internal nuclei
|
Disordered internal architecture
|
 Acid phosphatase stain |
 Acid phosphatase stain |
|
Acid phosphatase positive granules in fibers
|
|
Myotonic dystrophy (DM1): Mild changes |
|
 |
 |
|
Fiber size variation
Internal nuclei in some fibers |
Smaller type I (darker) fibers
Disordered internal architecture |
Myotonic dystrophy (DM2) |
|
 H & E stain |
 H & E stain |
|
Pyknotic nuclear clumps
|
Internal nuclei: Multiple
|
|
|
|
 Acid Phosphatase |
 ATPase pH 9.4 |
|
Cytoplasmic granules: Acid Phosphatase positive
|
Small fibers of both types
Internal nuclei (clear regions) most commonly in type 2 (dark) muscle fibers |
|
|
|
 NADH stain |
 Esterase |
|
Pyknotic nuclear clumps stain darkly
|
|
|
|
 From: Cory Toth MD |
|
Pyknotic nuclear clump: Ultrastructure
|