Neuromuscular

LIPID STORAGE

See: Differential Diagnosis


H & E stain

Gomori Trichrome stain

Sudan black stain

Lipid storage in a child:
  • Small, clear vacuoles, or droplets, are present on H & E and GT stains.
  • Sudan black stains large lipid droplets in type I muscle fibers.


Lipid storage in an adult with HIV
  • Small, clear vacuoles: H & E, GT & ATPase stains
  • Abnormal internal architecture with a punctate pattern: NADH & SDH
  • Large lipid droplets in type I muscle fibers: Sudan black

H & E stain

 

Gomori Trichrome stain

ATPase pH 9.4 stain

NADH stain

SDH stain

Sudan black stain

 


From: Cory Toth MD
Lipid droplets in a muscle fiber: Ultrastructure

Lipid storage in a muscle fiber

Neighboring muscle fibers with no lipid storage

Two muscle fibers with (above) and without (below) lipid storage

Lipid storage: Lipid droplets & Mitochondria



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Lipid myopathies: Classification

5/7/2011