Neuromuscular

Congenital MG: Agrin mutations


H&E stain
Muscle fibers
  Varied size
  Some internal nuclei

H&E stain

Gomori trichrome stain
Varied fiber size
Internal architecture: Irregular in some muscle fibers

NADH stain

ATPase pH 9.4 stain
Fiber types
  Types I & II are small and large
  Type IIC fibers are present

ATPase pH 4.3 stain
Neuromuscular junctions: Normal staining

Esterase stain

Esterase stain
Myotendinous junctions: Irregular shapes extending into muscle fibers

Esterase stain

Esterase stain

Caveolin-3 stain
Myotendinous junctions: Stain for sarcolemmal proteins

Dys2 stain

Internal architecture: Desmin aggregates

Desmin stain


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12/27/2014