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SEPN1 (CMYO3)

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Muscle Pathology

• Muscle fibers
• Fiber sizes: Varied
• Internal nuclei
• Internal architecture: "Minicores"; Aggregates (LC3)
• Fiber types: Scattered immature 2C fibers; 1 predominance, mild
• Endomysial connective tissue: Normal to mildly increased
• Young child: No prominent pathology

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25 year old female

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H&E stain

Muscle fiber sizes: Varied
Internal nuclei: some muscle fibers
Endomysial connective tissue: Midly increased

H&E stain

Gomori trichrome stain

Muscle fiber sizes: Varied
Endomysial connective tissue: Midly increased

VvG stain

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NADH stain

Internal Architecture
  Internal clear/pale regions with irregular borders

NADH stain

NADH stain

Cytochrome oxidase stain

Internal Architecture
  Internal clear/pale regions with irregular borders

Cytochrome oxidase stain

SDH stain

ATPase pH 4.3 stain

ATPase pH 4.3 stain

ATPase pH 9.4 stain

LC3 stain

Muscle fiber aggregates: stain for LC3

LC3 stain

UEA I stain

Endomysial capillaries: Normal

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2 year old female

H&E stain

Muscle fibers: Mildly varied sizes

VvG stain

NADH stain

Internal architecture: Mildly coarse, punctate

H&E stain

VvG stain

Gomori trichrome stain

Internal architecture: Mildly coarse, punctate

NADH stain

ATPase pH 9.4 stain

Fiber types: Mild non-random distribution

ATPase pH 4.3 stain

Cytochrome oxidase stain

Cytochrome oxidase stain

Mitochondria: No definite pathology

SDH stain

Sudan Black stain

Lipid droplets: Mildly large

Sudan Black stain

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PAS stain

Glyucogen: Normal

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AMPDA stain

Internal Architecture: Irregular in few fibers

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Return to: SEPN1

12/21/2024