Neuromuscular

RFC1: CANVAS



H&E stain
RFC1: Sural nerve
  Normal structure of connective tissue & vessels

H&E stain


VvG stain

Gomori trichrome stain
Myelinated Axons
  Reduced numbers

VvG stain

Endomysium
  Normal ATPase staining

ATPase pH 4.3 stain


Alkaline phosphatase stain
Endoneurial Microvessels
  Numbers: Normal to Increased
  Alkaline phosphatase staining: Reduced

UEAI stain


VvG stain
Epineurial Arteries
  Irregular inner fibril layer

VvG stain


Congo red stain

No endoneurial histiocytes

Acid phosphatase stain


Neurofilament stain
Axons
  Large: Severe loss
  Small, Unmyelinated: Relatively preserved

Neurofilament stain


Neurofilament (Green)-P0 (Red) stain
Axons
  Large: Severe loss

Neurofilament (Green)-MBP (Red) stain


Neurofilament (Green)-NCAM (Red) stain
Axons
  Small: Mild loss; Some non-myelinating Schwann cells have no axons (Red)

NCAM stain


NCAM (Green) - P0 (Red) stain
Schwann cell pathology: Chronic
  Büngner band cells (Yellow) present

Schwann cell pathology: Chronic
  Büngner band cells (Red) present
  Myelinated axons (Yellow): Reduced numbers

Periaxin (Green) - P0 (Red) stain

RFC1: Axons

Toluidine blue-stained Plastic sections
Axon loss
  Large & Small myelinated axons
Axon regeneration
  Clusters of small, thinly myelinated axons
Axon shapes
  Many irregularly shaped small myelinated axons

Toluidine blue-stained Plastic sections

Toluidine blue-stained Plastic sections
Axon loss
  Large & Small myelinated axons
Axon regeneration
  Clusters of small, thinly myelinated axons
Axon shapes
  Many irregularly shaped small myelinated axons

Toluidine blue-stained Plastic sections

Toluidine blue-stained Plastic sections

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3/22/2022