Renaut Bodies ¹

Patterns   Confluent   Internal   Typical Renaut illustration

Reference 2

Renaut bodies: Features

• Frequency
  • 2% of nerve biopsies
  • Increased age: Possibly more frequent
• Structure
  • Shape: Round, Elliptical (Flattened) or Elongated (Along length of nerve)
  • Internal: Whorled
  • Contents
    • Cell: Fibroblasts, often with long processes; "Spider-like" (cellules godronées)
    • Other: Mucopolysaccharides; Collagen; Elastin
  • Edge: May be bounded by fibroblast process
  • Size: 20 to 130 μM
• Location
  • General: At sites of nerve compression
  • Intraneural: Endoneurial
    • Usual: Subperineurial
    • Internal: Internal within endomysium
• Often multiple: In several fascicles in nerve
  • Usual: All in similar region of different fascicles
  • Atypical: Confluent
  • May be 1, or several, in individual fascicles
• Stains: Alcian blue; Gomori trichrome; ± EMA
• Associated vessels: May have thick wall
• Possible cause: Chronic nerve compression

Renaut Bodies: Typical

Gomori trichrome stain

Toluidine blue stain

VvG stain

Gomori trichrome stain

H&E stain

H&E stain

Gomori trichrome stain

Gomori trichrome stain

VvG stain

Toluidine blue stain

Alcian blue stain

Alcian blue stain

Alcian blue stain

Renaut Bodies: Confluent

Toluidine blue stain

Toluidine blue stain

Toluidine blue stain

Toluidine blue stain

Toluidine blue stain

Alcian blue stain

Alcian blue stain

Renaut Bodies: Internal

H&E stain

Gomori trichrome stain

Congo red stain

Gomori trichrome stain

Congo red stain

Alcian blue stain

Alcian blue stain

Renaut body: Renaut illustration

H&E stain

gomori Trichrome stain

VvG stain