Neuromuscular

Marinesco-Sjögren Syndrome

From: I Nishino


H&E stain

Muscle fiber size: Varied
Endomysial connective tissue: Mildly increased
Vacuole (1 fiber): Contains basophilic material

H&E stain

Muscle fiber size: Varied
  Scattered very small fibers
  Some small fibers are basophilic
Internal nuclei


H&E stain

Muscle fiber with large vacuole
  Vacuole contains basophilic material

Gomori trichrome stain

Muscle fiber with vacuole
  Vacuole contains red material


Gomori trichrome stain

Muscle fiber with 2 vacuoles
  Vacuoles contain red material
  Nucleus is adjacent to 1 vacuole

Non-specific esterase stain

Nuclear staining within several fibers


NADH stain



ATPase pH 10.5 stain


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6/3/2008