IBM3: Adult; MYH2 H&E stain Fiber sizes: Marked variation; Hypertrophy & Atrophy Internal nuclei: Many fibers Small fibers: Rounded; Some large pyknotic nuclear clumps Large fibers: Partial fusion  H&E stain  H&E stain Muscle fiber pathology Vacuoles Internal nuclei Partial fusion Pyknotic nuclear clumps  Congo red stain  Congo red stain Vacuoles: Contain basophilic granular debris  Congo red stain  Congo red stain Nuclei: Large; Internal  ATPase pH 9.4 stain Type 2 fiber predominance: Many fibers are 2C  ATPase pH 4.3 stain  NADH stain Internal architecture Some small fibers are dark stained Large fibers have irregular staining |
Fiber Type Abnormalities
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Type 2 fibers (H): Commonly express multiple MYH types (MYH7, MYH2, MYH1& MYH4)
Branched fibers (B) are present
Return to Neuromuscular
Return to MYH2
11/14/2021