IBM3: Adult; MYH2![]() H&E stain Fiber sizes: Marked variation; Hypertrophy & Atrophy Internal nuclei: Many fibers Small fibers: Rounded; Some large pyknotic nuclear clumps Large fibers: Partial fusion ![]() H&E stain ![]() H&E stain Muscle fiber pathology Vacuoles Internal nuclei Partial fusion Pyknotic nuclear clumps ![]() Congo red stain ![]() Congo red stain Vacuoles: Contain basophilic granular debris ![]() Congo red stain ![]() Congo red stain Nuclei: Large; Internal ![]() ATPase pH 9.4 stain Type 2 fiber predominance: Many fibers are 2C ![]() ATPase pH 4.3 stain ![]() NADH stain Internal architecture Some small fibers are dark stained Large fibers have irregular staining |
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