Multicores
Mutliple internal clear zones in muscle fibers
Myopathic changes in multicore disease
- Fiber size: Variability
- Internal nuclei: Many fibers
NADH stain
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Minicore-like lesions in muscle with denervation changes: Adult
Patient: 2 year old female with noncompaction cardiomyopathy, hypotonia & developmental delay
Genetics: Titin mutations K2186C & D19486Y
From Chunyu (Hunter) Cai
H&E stain
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Myopathic features
Fiber sizes: Abnormal variation
Internal nuclei
NADH stain
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Minicores
ATPase pH 9.4 stain
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Fiber types
Type 1 fibers: Predominance; Smallness
Muscle Multi/Minicores: Ultrastructure
Horizontal Z band streaming: Multifocal regions
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Multicore myopathy
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2/16/2018
