CONGENITAL MUSCULAR DYSTROPHY: Laminin-α2 (Merosin) Negative
 H&E stain |
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Congenital muscular dystrophy: Myopathic changes Muscle fibers Size: Marked Variability Immature fibers: Internal nuclei; Basophilic cytoplasm Connective tissue Endomysium: Increased between muscle fibers Perimysium: Widened  H&E stain |
   <H&E stain |
 H&E stain |
 GT stain |
Endomysial connective tissue: Increased
Muscle fiber size: Varied
 VvG stain |
Congenital muscular dystrophy: Other changes
Many immature (Type 2C) intermediate-staining muscle fibers ATPase pH 4.3 stain |
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Muscle Fiber Necrosis, Minor Occasional acid phosphatase positive cells  Acid phosphatase stain |
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Laminin-α2 (Merosin) staining | |
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Laminin-α2: Normal muscle Merosin is normally located in: Basal lamina: Muscle fiber surface Intramuscular nerves |
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Laminin-α2: Congenital muscular dystrophy Laminin-α2 staining is absent from muscle fiber surfaces |
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5/23/2017