CONGENITAL MUSCULAR DYSTROPHY: Laminin-α2 (Merosin) Negative

H&E stain
Congenital muscular dystrophy: Myopathic changes
  Muscle fibers
    Size: Marked Variability
    Immature fibers: Internal nuclei; Basophilic cytoplasm
  Connective tissue
    Endomysium: Increased between muscle fibers
    Perimysium: Widened

H&E stain


H&E stain

H&E stain

GT stain
CMD: Laminin-α2 (Merosin) Negative
  Endomysial connective tissue: Increased
  Muscle fiber size: Varied

VvG stain

Congenital muscular dystrophy: Other changes

Many immature (Type 2C) intermediate-staining muscle fibers

ATPase pH 4.3 stain

Muscle Fiber Necrosis, Minor
  Occasional acid phosphatase positive cells

Acid phosphatase stain

Laminin-α2 (Merosin) staining
Laminin-α2: Normal muscle

Merosin is normally located in:
  Basal lamina: Muscle fiber surface
  Intramuscular nerves

Laminin-α2: Congenital muscular dystrophy

  Laminin-α2 staining is absent from muscle fiber surfaces

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