Neuromuscular

CALCIPHYLAXIS

H & E stain
Calcification of perimysial vessel walls

H & E stain

Congo Red stain

Alizarin red stain
Calcium deposited in vessel walls

Alizarin red stain
Calcium deposited in capillaries

Alizarin red stain

Muscle pathology in calciphylaxis


H & E stain
Muscle fiber pathology in calciphylaxis
  Fiber sizes: Varied; Bimodal distribution
  Myonuclei: Large; Irregular shapes

H & E stain
Muscle fiber pathology in calciphylaxis
  Fiber sizes: Varied; Bimodal distribution
  Small muscle fibers: Angular
  Myonuclei: Large; Irregular shapes   Endomysial capillaries: Some are large

H & E stain

Gomori Trichrome stain
Muscle fiber pathology in calciphylaxis
  Fiber sizes: Varied; Bimodal distribution
  Small muscle fibers: Angular
  Endomysial capillaries: Some are large

NADH stain
Muscle pathology in calciphylaxis
  Muscle fiber internal architecture: Irregular
  Endomysial capillaries: Large (Below)

NADH stain
Endomysial capillaries: Pathology in calciphylaxis
  Large
  Misoriented (Circumferential around muscle fibers

UEA I stain
Muscle pathology in calciphylaxis
  Endomysial capillaries: Large

UEA I stain
Variable fiber size Type 2 atrophy
Muscle pathology in calciphylaxis
  Muscle fiber sizes
    Varied
    Atrophy: Most fibers
    Type 2 muscle fibers: Smaller than type 1
  Perimysial connective tissue
    Replaced by fat

ATPase pH 4.3 stain
Alkaline phosphatase Hemosiderin
Subcutaneous tissue pathology in caliciphylaxis
  • Alkaline phosphatase staining
  • Hemosiderin deposits
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1/31/2022