Neuromuscular

Orbital Myositis


H&E stain
Multifocal Inflammatory Myopathy
  Multiple scattered foci of lymphocytes

CD3 (T-cell) stain


H&E stain
Cell foci: Features of Germinal centers (Ectopic lymphoid structures (ELS)) 1
  Contain
    Smaller vessels (High endothelial venules)
    B-cells and T-cells
  Locations
    Endomysium: Between muscle fibers
    Perimysium: Between fascicles

H&E stain


H&E stain
Inflammatory Cells
  In foci
    Common: B-cells & T-cells
    Scattered: Plasma cells
    Few: Eosinophils

H&E stain

H&E stain

T/B Cell Separation

CD20 (B-cell) stain
B-cells & T-cells: Occupy somewhat different areas in cell foci

CD3 (T-cell) stain

CD20 (B-cell) stain
B-cells & T-cells: Occupy somewhat different areas in cell foci

CD3 (T-cell) stain


H& E stain
Plasma Cells: Scattered in regions other than lymphocytic foci

CD138 (Plasma cell) stain

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References
1. Nat Rev Immunol 2014;14:447-462, Front Immunol 2016;7:430

3/11/2017