Neuromuscular

Myhre Syndrome: Muscle Pathology

  • Muscle fibers
    • Fiber types: 2C fibers with normal morphology increased
    • Fiber size: Mildly varied
  • Connective tissue: Increased histiocytic cells; Whorled structure
  • Elastin fibrils: Thin & Irregular in Vessels & Connective tissue

H&E stain

H&E stain

Type 2C fibers: Common

ATPase pH 4.3 stain


Gomori trichrome stain

VvG stain
Perimysial Connective tissue
  Whorled structure
  Fibrils: Irregular
  Histiocytic cells: Increased

Acid phosphatase stain

NADH stain
Perimysial Cells
  Stain for NADH & Caveolin-3


Caveolin-3 stain


Perimysium
  Elastin fibrils: Thin & Branched
  Vessels: Elastin fibrils thin & wavy

VvG stain

VvG stain

VvG stain

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7/30/2016