Neuromuscular

HIV: Immune Reconstitution Inflammatory Syndrome (IRIS)


H & E stain
Muscle fibers: Atrophy; Internal nuclei
Inflammation: Large cells in endomysium

H & E stain

H & E stain

Endomysial vessels: Large size; Thick walls; Large endothelial cells (Arrow)

H & E stain


Gomori trichrome stain
Endomysial connective tissue: Mildly increased
Muscle fibers: Varied size; Cytoplasmic bodies in some fibers

Gomori trichrome stain
Cytoplasmic bodies: Many, clustered, in one muscle fiber

Gomori trichrome stain

Endomysial capillaries: Large size; Thick wall; Enlarged endothelial cells

Gomori trichrome stain


VvG stain
Muscle fibers: Varied sizes
Inflammatory cells: Scattered in endomysium between muscle fibers

VvG stain

Inflammatory cells: Scattered in endomysium between muscle fibers

Congo red stain

Immature muscle fibers: Intermediate stained (2C)

ATPase pH 4.3 stain

Immature muscle fibers: Coarse internal architecture

NADH stain


Esterase stain
Histiocytes: Large, irregular shaped cells are scattered in the endomysium

Esterase stain

Histiocytes: Stain with acid phosphatase

Acid phosphatase stain

Immature muscle fibers: A few small fibers stain for alkaline phosphatase

Alkaline phosphatase stain

Mitochondrial proliferation: Increased staining in scattered muscle fibers

Succinate Dehydrogenase (SDH) stain
COX negative muscle fibers: Some fibers do not stain for COX

Cytochrome oxidase (COX) stain

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2/11/2015