CONGENITAL MUSCULAR DYSTROPHY (Merosin -): PATHOLOGY

H&E stain

Myopathic changes in congenital muscular dystrophy Fiber size: Variability Immature muscle fibers (Center): Internal nuclei; Basophilia Connective tissue (Right): Increased

Merosin: Normal muscle Merosin is normally located in:   Basal lamina: Muscle fiber surface   Intramuscular nerves	Merosin: Congenital muscular dystrophy   Merosin staining is absent from   the muscle fiber surface