Neuromuscular

Unknowns: Inflammation & Immunity


A

H & E stain
What is the most likely diagnosis?


B

H & E stain
How would you interpret this finding?


C

Alkaline phosphatase stain
Alkaline phosphatase diffusely stains the perimysium in this low power image of a muscle.
How would you interpret this pattern of abnormality?


D

H & E stain
What is wrong with the muscle fiber?
How would you interpret this finding?
What other stains might be performed to clarify the disease process?


E

Congo red stain
What does this pattern of focal cellularity suggest?
What additional stains would be useful to confirm your impression?


F

H&E stain
What does this pattern of pathology suggest?
What additional stains would be useful to confirm your impression?


G

H&E stain
47 year old female with recent onset bulbar and proximal arm weakness and normal serum CK.
What does this pattern of inflammation suggest?
What additional tests would be useful to confirm your impression?




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12/31/2010