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TRICHINOSIS: ACUTE

Cyst with larvae: Active phase of infection
Congo red stain	Gomori trichrome stain
Larvae are in cysts within muscle Each cyst contains one coiled larva Cysts also contain "nurse" cells with large nuclei (Arrow) The outer edge of the cyst is a well-defined wall (Arrowhead) There is little inflammation around well-formed cysts

Alkaline phosphatase stain	PAS stain
Contents of cyst around larvae stain with alkaline phosphatase. Cyst wall and larva contain carbohydrate and stain with PAS.

Inflammation near unencysted larvae
H&E stain	Acid phosphatase stain
Inflammation near larva may include multinucleated giant cells Many of the cells in the infiltrates are histiocytes (macrophages) that Contain nuclei that are larger and paler than those in T-cells (Left) Stain with acid phosphatase (Right)